Analysis Of Ambroxol Hydrochloride In Flavamed® Tablets By Means Of Spectroscopic Absorption Methods
Quality of Life (Banja Luka) 7(1-2): 24-28
Analysis Of Ambroxol Hydrochloride In Flavamed® Tablets By Means Of Spectroscopic Absorption Methods
Dijana Jelić*1, Saida Fazlagić1, Vesna Antunović1,
Nataša Bubić-Pajić1, Anđelka Račić1 and Mirjana Đermanović2
1University of Banja Luka, Medical faculty, Pharmacy Department,
Bulevar Vojvode Petra Bojovića 1a, 78000 Banja Luka, Bosnia and Herzegovina
2Institute of Public Health of Republic of Srpska, Jovana Dučića 1, 78000 Banja Luka, Bosnia and Herzegovina
Abstract: Ambroxol hydrochloride (AMB), (1s,4s)-4-((2-amino-3,5-dibromocyclohexyl)methylamino) cyclohexanol hydrochloride, is semi - synthetic derivative of vasicine obtained from Indian shrub Adhatoda vasica. It is a metabolic product of bromhexin and it is used as broncho secretolytic and an expectorant drug. Analysis of Flavamed® tablets, in which ambroxol hydrochloride (AMB) is an active component, was performed. UV/VIS spectrophotometry and atomic absorption spectroscopy (AAS) were used. Direct and indirect UV/VIS spectrophotometric methods were used for quantitative analysis of AMB and the following recovery value results were obtained: 100,16% and 95,23%, successively. Content of heavy metals in Flavamed® tablets was determined by atomic absorption spetroscopy.
Key words: Ambroxol hydrohloride, Flavamed tabletes, Spectroscopic analysis
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