Quality of Life (Banja Luka) 11(1-2): 25-30


Analysis of Contents of Calcium, Magnesium and Total Hardness in Water for Pharmaceutical Use

Mirjana Đermanović, Ljubica Bojanić, Biljana Vučić

1 Institute of Public Health of Republic of Srpska, Banja Luka, Bosnia and Herzegovina, 
2 University of Banja Luka, Faculty of Medicine, Pharmacy department, Banja Luka,


Аbstract: Water is one of the most frequently used raw materials in pharmaceutical industry. Water for pharmaceutical purposes includes the two primary water types: purifi ed water and water for injection. Drinking water used for obtaining purifi ed water is not offi cial in pharmacopoeia. Depending on quality prescribed for a certain product preparation, various water types and procedures have been used to prepare pharmaceutical industry water. Possible ways to obtain water for pharmaceutical purposes are: reverse osmosis, demineralization, electrodeionization, ultrafi ltration, distillation. Reasons for the widespread use of water lie in the facts that it is capable of dissolving a great number of therapeutic substances, compatible with a large number of substances, appropriate to be used from a physiological aspect given that it is an integral part of the cell and the major component of body fl uids and whenever the drug is administered in the form of an aqueous solution, reabsorption is rapid and complete, it also has suitable physical-chemical properties. In this study, analysis results of 15 samples of water were obtained using pharmacopoeial methods for pharmaceutical purposes. Results showed that 86.6% of water samples were accurate and 13.3% did not have appropriate calcium content,magnesium content and total hardness values.
Keywords: water, pharmaceutical purposes, calcium, magnesium, total hardness
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